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animal vaccine

Improving Human Wellness Through Innovative Recombinant Protein Biotechnology

Pipeline

“Veterinary Vaccine”

01Foot and Mouth Disease Virus (FMDV) Vaccine
One of the world’s most-feared and economically important disease of livestock animal.
FMDV is highly contagious, genetically variable and resistant to environmental condition
Foot and Mouth Disease (FMD)

Highly contagious and affects cloven-hoofed farmed animals

Strong resistance to environmental condition. Long distance (>100 Km) transmission of FMDV through the air to cattle is possible

Transportation of infected animals can seed new outbreaks in diverse locations.

Unmet Needs of licensed inactivated FMDV vaccine

Poor Efficacy – low immunogenicity & protective immunity

Severe unwanted effect

Slow-rate & low-yield manufacturing process

Competitiveness of InThera’s FMDV Vaccine

Improved efficacy as VLP Vaccine

Reduced unwanted effect due to high content purified capsid proteins

High yield and fast production in E.coli

suitable for multivalent vaccine
production in response to urgent outbreaks

02Feline Calicivirus (FCV) Vaccine
FCV infection causes an upper respiratory tract disease (URTD) in cats. Market demands for innovative vaccine with improved efficacy & safety profile is very high.
Feline Calicivirus (FCV) Infection

Affect about 50% of cats with upper respiratory infections

One of the two important viral causes of respiratory infection in cats, the other being feline herpesvirus

Acute signs of FCV include fever, conjunctivitis, nasal discharge, sneezing, and ulceration of the mouth (stomatitis). Pneumonia may develop with secondary bacterial infections.

Latent or subclinical infections often become clinical when the cat is stressed

Unmet Needs of conventional FCV vaccine

Despite widespread vaccination with attenuated virus, FCV related illnesses still occurs among vaccinated cats.

Two types of FCV vaccines , inactivated and attenuated vaccine

Severe unwanted effect

- Attenuated FCV vaccine : possibly cause mild upper respiratory infection.

- Inactivated vaccine - causes more local inflammation and possibly vaccine associated sarcoma

Competitiveness of InThera’s FCV Vaccine

Improved efficacy & safety profile as VLP Vaccine

High yield and fast production in E.coli ▶ suitable for high quality and affordable vaccine for companion animal